The 30-share BSE Sensex was down 73.28 points at 35,103.14 and the 50-share NSE Nifty fell 38.30 points to 10,679.70.
According to market observers, heavy selling pressure was witnessed in the auto, healthcare and metal stocks.
Among other Asian markets, Japan's Nikkei was down 0.32 per cent while Hong Kong's Hang Seng shed 0.47 per cent in early trade today.
Shares of InterGlobe Aviation, after slumping almost 20 per cent in early deals, clawed back some lost ground to end 10.57 per cent lower after the company yesterday reported a 73 per cent plunge in profit for the March quarter.
The Sensex touched a high of 35,257.31 points and a low of 35,020.08 during the intra-day trade.
The BSE market breadth was bearish with 1,575 declines and 1,121 advances. "Sentiments were hit on the back of data showing that FPIs and domestic institutional investors turned net sellers of Indian stocks yesterday", Deepak Jasani, Head, Retail Research, HDFC Securities, told IANS.
"Rupee weakened as positive US employment data might lead to (US) Feds monetary tightening".
Global cues too were weak as investors eyed the outcome of US-China trade talks as well as the US jobs report.
Market participants booked profits at higher levels in opening trade, they added. The index had gained almost 12 percent in the previous month on the back of a weaker rupee and strong earnings from IT majors.
Bharti Airtel, HUL, Adani Ports, ONGC, Dr. Reddy's, SBI, TCS, IndusInd Bank, Yes Bank, HDFC Bank, TCS and L&T rising up to 2.45 percent.
Pharma stocks pushed both indexes lower, with the Nifty Pharma index falling as much as 1 percent.
Numerous former coaches and team-mates of Gerrard have had their say on the ex-England star taking up the role at Ibrox. He admitted he had held talks and they were resumed on Thursday as the two parties looked to thrash out terms.
Its 2017 revenue surged by 67.5% to 114.6 billion yuan ($18 billion), with overseas sales more than tripling to 32.1 billion yuan. Lei has pledged to reclaim the top spot in China in the next 10 quarters, but it won't be easy in a declining smartphone market.
They also agreed to achieve a nuclear-free Korean Peninsula, but failed to produce specific time frames and disarmament steps. Presidents Theodore Roosevelt, Woodrow Wilson, Jimmy Carter and most recently Barack Obama are all Nobel winners.
The PM2.5 includes pollutants like sulfate, nitrate and black carbon, which pose the greatest risk to human health. In some regions, sand and desert dust, waste burning and deforestation are additional sources of air pollution.
An explosion in CT on Wednesday injured four police officers responding to a domestic violence report , local media reported. A house in North Haven exploded Wednesday night and a massive fire is burning. "It's a shock.
Around 100 students walked out of Grand Ledge High School in MI , where they gathered around a flagpole in front of the school. At 9:55 a.m., up to 100 students gathered outside of the school with a few students carrying flags across the parking lot.
This handsome day will be made more special with the love and support of our family of fans & well-wishers. Anushka Sharma , one of India's most popular film artists, celebrated her 30th birthday on 1st May, 2018.
Unlike his siblings Prince George , 4, and Princess Charlotte , 2, Louis' birth certificate is typed and not handwritten. A beloved mentor of Prince Charles, he was assassinated in 1979 by the Irish Republican Army.
The 167-kilometre second stage on Saturday (Sunday NZT) will whizz down the Mediterranean coast from Haifa to Tel Aviv. Froome was pictured with a ripped jersey and shorts and cuts around his hip and right knee as his bike was repaired.
The three individuals - Kim Dong Chul , Kim Hak-song and Kim Sang-duk - are the last Americans being held by the reclusive nation. Kim Sang-deok formerly taught accounting at Yanbian University of Science and Technology in China , near the North Korean border.
Beasts battle: CSK vs KKR
The Chennai Super Kings on the other hand have lesser issues to address. "This is what I discussed with DK (Karthik)", Gill said. Weather: There are chances of rain in Kolkata but the drainage system is quite good, so there might not be a lot to worry about.
Bill Clinton's impeachment lawyer to represent Trump
Among the materials they sought were communications between Trump and Cohen in the lead-up to the election. John Dowd , the leading lawyer representing Trump in special counsel matters, left the team in March.
Apple's Latest Earnings Debunks 'Disappointing' iPhone X Sales
An average iPhone was sold for $728 during the quarter, up from $655 a year ago, said CFO Luca Maestri during the investor call. He said the ASP growth was "mainly driven by iPhone X ", indicating the $1000 price point had worked in the company's favour.